Plenary Paper CLINICAL TRIALS AND OBSERVATIONS A 1-year randomized controlled trial of deferasirox vs deferoxamine for myocardial iron removal in b-thalassemia major (CORDELIA)
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چکیده
A 1-year randomized controlled trial of deferasirox vs deferoxamine for myocardial iron removal in b-thalassemia major (CORDELIA) Dudley J. Pennell, John B. Porter, Antonio Piga, Yongrong Lai, Amal El-Beshlawy, Khawla M. Belhoul, Mohsen Elalfy, Akif Yesilipek, Yurdanur Kilinç, Tomasz Lawniczek, Dany Habr, Marianne Weisskopf, Yiyun Zhang, and Yesim Aydinok, on behalf of the CORDELIA study investigators
منابع مشابه
CLINICAL TRIALS AND OBSERVATIONS Effect of transfusional iron intake on response to chelation therapy in -thalassemia major
The success of chelation therapy in controlling iron overload in patients with thalassemia major is highly variable and may partly depend on the rate of transfusional iron loading. Using data from the 1-year phase III study of deferasirox, including volumes of transfused red blood cells and changes in liver iron concentration (LIC) in 541 patients, the effect of iron loading on achieving neutra...
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1American University of Beirut, Beirut, Lebanon; 2University College London, London, United Kingdom; 3Department of Pediatrics and Internal Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; 4First Department of Pediatrics, University of Athens, Athens, Greece; 5Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 6Chulalongkorn University and King Chulalongkorn Memorial...
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The optimal regimen of intravenous deferoxamine for iron overload in high-risk homozygous b-thalassemia is unknown because only short-term follow-up has been described in small patient groups. We report the outcome over a 16-year period of a continuous 24-hour deferoxamine regimen, with dose adjustment for serum ferritin, delivered via 25 indwelling intravenous lines for 17 patients. Treatment ...
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Stroke is a devastating complication of sickle cell anemia (SCA) with high recurrence if untreated. Chronic transfusions reduce recurrent strokes but have associated morbidities including iron overload. Stroke With Transfusions Changing to Hydroxyurea (SWiTCH) was a multicenter phase 3 randomized trial comparing standard treatment (transfusions/chelation) to alternative treatment (hydroxyurea/p...
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1The Catholic University of Korea, Seoul, South Korea; 2Seoul National University College of Medicine, Seoul, South Korea; 3Ruijin Hospital, Shanghai Second Medical University, Shanghai, China; 4Medizinische Hochschule Hannover, Hannover, Germany; 5Taipei City Hospital, Taipei, Taiwan; 6Novartis Pharmaceuticals, East Hanover, NJ; 7Novartis Pharma AG, Basel, Switzerland; and 8University College ...
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تاریخ انتشار 2014